Cosyrel, Bisoprolol/Perindopril, 5 Mg/10 Mg - 30 Tablets

Product Name

• Cosyrel, Bisoprolol/Perindopril, 5 Mg/10 Mg - 30 Tablets

Scientific Name

• Bisoprolol 5 Mg + Perindopril 10 Mg Tablets

Category Of Cosyrel Tablets

• Antihypertensive drugs

Mechanism Of Action Of Bisoprolol

• Perindopril belongs to Angiotensin-converting-enzyme inhibitors which are a class of medication used primarily for the treatment of high blood pressure and heart failure. They work by causing relaxation of blood vessels as well as a decrease in blood volume, which leads to lower blood pressure and decreased oxygen demand from the heart.
• In addition, Perindopril blocks the conversion of angiotensin I to angiotensin II and prevents the degradation of vasodilator prostaglandins, thereby inhibiting systemic vasoconstriction, regulated by angiotensin II, and promoting systemic vasodilation.
• Bisoprolol blocks beta-adrenergic stimulation; cardioselective for beta-1 at low doses with little or no effect on beta-2 receptors at doses ≤ 20 mg.
• Bisoprolol is a beta-blocker that protects the heart from too much activity. This medicine works by affecting the body’s response to some

Therapeutic Indications Of Cosyrel Tablets

• Hypertension: High blood pressure is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease.

Method Of Administration Of Cosyrel Tablets

• Treatment with Bisoprolol fumarate tablets must be started at a low dose and increased gradually.
• Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
• If you take more than you should, talk to a doctor or go to the hospital straight away.
• If you forget to take a dose, just take your next dose as normal.
• Do not take a double dose (two doses at the same time) to make up for the forgotten dose

Undesirable Side Effects Of Cosyrel Tablets

• Dizziness 
• Insomnia
• Bradyarrhythmia 

Pregnancy & Breastfeeding Precautions While Taking Cosyrel Tablets

• Use is recommended only if needed and the benefit outweighs the risk to the fetus.
• Exercise caution when therapy is administered to a nursing woman

Non-Pharmacological Treatments & Advice For Hypertensive Patients

• To measure blood pressure correctly:

1. Don’t eat or drink anything 30 minutes before you take your blood pressure.
2. Empty your bladder before your reading.
3. Sit in a comfortable chair with your back supported for at least 5 minutes before your reading.
4. Put both feet flat on the ground and keep your legs uncrossed.
5. Rest your arm with the cuff on a table at chest height.
6. Make sure the blood pressure cuff is snug but not too tight. The cuff should be against your bare skin, not over clothing.
7. Do not talk while your blood pressure is being measured.

• You will also find the following Non-Pharmacological treatment effective:

1. Lose extra pounds and watch your waistline
2. Exercise regularly
3. Eat a healthy diet
4. Reduce sodium in your diet
5. Quit smoking
6. Cut back on caffeine
7. Reduce your stress
8. Monitor your blood pressure at home and see your doctor regularly

Warnings & Special Precautions While Taking Cosyrel Tablets

• Drugs Should never be stopped suddenly
• Consult your doctor or pharmacist before use if you suffer from any other disease

• Tell your doctor or pharmacist about your medications

Storage Conditions Of Cosyrel Tablets

• store below 25°c
• Keep this medicine out of the sight and reach of children.
• Store in the original package to protect from moisture.
• Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month.
• Do not throw away any medicines via wastewater or household waste.

Normal Range

• Normal: Blood pressure numbers of less than 120/80 mm Hg
• Elevated: is when readings consistently range from 120-129 systolic and less than 80 mm Hg diastolic.
• Hypertension Stage 1: is when blood pressure consistently ranges from 130-139 systolic or 80-89 mm Hg diastolic.
• Hypertension Stage 2: is when blood pressure consistently ranges at 140/90 mm Hg or higher.
• Hypertensive crisis: This stage of high blood pressure requires medical attention. If your blood pressure readings suddenly exceed 180/120 mm Hg, wait five minutes and then test your blood pressure again. If your readings are still unusually high, contact your doctor immediately. You could be experiencing a hypertensive crisis.

For More Information about Bisoprolol

• Ask your physician or pharmacist
• Visit SFDA website
• Visit Medscape at Information about Bisoprolol
• Visit Drugbank at Information about Bisoprolol
• Visit Drugs.com at Information about Bisoprolol